It's possible for different devices to share an interrupt (for example if you've run out of hardware interrupt lines), but we don't recommend you do this with hardware that will be generating a lot of interrupts. We also recommend you not share interrupts with drivers that you don't have complete source control over, because you need to be sure that the drivers process interrupts properly.
Sharing interrupts can decrease your performance, because when the interrupt fires, all of the devices sharing the interrupt need to run and check to see if it's for them. Many drivers read the registers in their interrupt handlers to see if the interrupt is really for them, and then ignore it if it isn't. But some drivers don't; they schedule their thread-level event handlers to check their hardware, which is inefficient and reduces performance.
Sharing interrupts can increase interrupt latency, depending upon exactly what each of the drivers does. After an interrupt fires, the kernel doesn't reenable it until all driver handlers tell the kernel that they've finished handling it. If one driver takes a long time servicing a shared interrupt that's masked, and another device on the same interrupt causes an interrupt during that time period, the processing of that interrupt can be delayed for an unknown length of time.